Product classification

557-66-4

Product Name：Ethanamine,hydrochloride (1:1)
Molecular Formula：C₂H₇N^.HCl
Purity：99%
Molecular Weight：

Inquiry

Product Details;

CasNo： 557-66-4

Molecular Formula： C₂H₇N^.HCl

Appearance： white to off-white crystals

557-66-4 Properties

Molecular Formula:C2H7N^.HCl
Molecular Weight:81.5452
Appearance/Colour:white to off-white crystals
Vapor Pressure:1130mmHg at 25°C
Melting Point:107-108 °C(lit.)
Refractive Index:1.4202 (estimate)
Boiling Point:14.2 °C at 760 mmHg
PSA：26.02000
Density:1,22 g/cm3
LogP:1.46730

557-66-4 Usage

Chemical Properties

white to off-white crystals

Uses

Ethylamine Hydrochloride a chemical used in various chemical organic syntheses and biological studies. It is used in production of resins and rubber latex; also used in oil refining and organic syntheses.

Application

Ethylaminehydrochloride is used as a raw material for organic synthesis. Its free base ethylamine is used in the diethyldiazene, dimethylolethyltriazone, ethylcyanopyrolidone disperse and 1,3-diethylthiourea. It is a precursor used for the preparation of benzilnitrate, detergents, rayon, rocket propellant and alkyl isocyanates, which finds application in the manufacture of pharmaceuticals.

Preparation

Ethylamine can be synthesized by ethanol and ammonia are combined in the presence of an oxide catalyst:CH3CH2OH + NH3 → CH3CH2NH2 + H2OEthylamine could then be solvent extracted or boiled out of hoffman turned to Hydrochloride with HCl and then freebased with caustic to be distilled pure.of course an excess of caustic when freebasing would be a good idea as it would hold onto most of the water created from the basing of a hydrochloride with caustic.

Purification Methods

Crystallise the hydrochloride from absolute EtOH or MeOH/CHCl3, wash with dry ether and dry it in a vacuum. [Beilstein 4 IV 310.]

Precautions

Hygroscopic. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

InChI:InChI=1/C2H7N.ClH/c1-2-3;/h2-3H2,1H3;1H

557-66-4 Relevant articles

Green method for catalyzing reduction reaction of aliphatic nitro derivative

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Paragraph 0005-0006; 0009-0012, (2021/07/31)

The invention relates to a green method for catalyzing reduction reaction of aliphatic nitro derivatives. According to the method, non-transition metal compounds, namely triethyl boron and potassium tert-butoxide, are used as a catalytic system for the first time, an aliphatic nitro derivative and pinacolborane which is low in price and easy to obtain are catalyzed to be subjected to a reduction reaction under mild conditions, and an aliphatic amine hydrochloride product is synthesized after acidification with a hydrochloric acid aqueous solution. Compared with a traditional method, the method generally has the advantages that the catalyst is cheap and easy to obtain, operation is convenient, and reaction is safe. The selective reduction reaction of the aliphatic nitro derivative catalyzed by the non-transition metal catalyst and pinacol borane is realized for the first time, and the aliphatic amine hydrochloride product is synthesized through acidification treatment of the hydrochloric acid aqueous solution, so that a practical new reaction strategy is provided for laboratory preparation or industrial production.

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

Gudun, Kristina A.,Hayrapetyan, Davit,Khalimon, Andrey Y.,Segizbayev, Medet,Slamova, Ainur,Zakarina, Raikhan

, (2021/11/30)

The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

Bera, Jitendra K.,Pandey, Pragati

supporting information, p. 9204 - 9207 (2021/09/20)

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

Transition metal-free catalytic reduction of primary amides using an abnormal NHC based potassium complex: Integrating nucleophilicity with Lewis acidic activation

Bhunia, Mrinal,Sahoo, Sumeet Ranjan,Das, Arpan,Ahmed, Jasimuddin,Sreejyothi,Mandal, Swadhin K.

, p. 1848 - 1854 (2020/03/03)

An abnormal N-heterocyclic carbene (aNHC) based potassium complex was used as a transition metal-free catalyst for reduction of primary amides to corresponding primary amines under ambient conditions. Only 2 mol% loading of the catalyst exhibits a broad substrate scope including aromatic, aliphatic and heterocyclic primary amides with excellent functional group tolerance. This method was applicable for reduction of chiral amides and utilized for the synthesis of pharmaceutically valuable precursors on a gram scale. During mechanistic investigation, several intermediates were isolated and characterized through spectroscopic techniques and one of the catalytic intermediates was characterized through single-crystal XRD. A well-defined catalyst and isolable intermediate along with several stoichiometric experiments, in situ NMR experiments and the DFT study helped us to sketch the mechanistic pathway for this reduction process unravelling the dual role of the catalyst involving nucleophilic activation by aNHC along with Lewis acidic activation by K ions.