Product classification

2343-89-7

Product Name：2-Propenoic acid,2-fluoro-, methyl ester
Molecular Formula：C₄H₅FO₂
Purity：99%
Molecular Weight：

Inquiry

Product Details;

CasNo： 2343-89-7

Molecular Formula： C₄H₅FO₂

2343-89-7 Properties

Molecular Formula:C4H5FO2
Molecular Weight:104.081
Vapor Pressure:103mmHg at 25°C
Refractive Index:1.39
Boiling Point:75.9 °C at 760 mmHg
Flash Point:1.1 °C
PSA：26.30000
Density:1.057 g/cm³
LogP:0.64260

2343-89-7 Usage

Chemical Properties

Clear colorless liquid

Uses

Methyl 2-fluoroacrylate is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Synthesis Reference(s)

Synthetic Communications, 11, p. 901, 1981 DOI: 10.1080/00397918108065745

InChI:InChI=1/C4H5FO2/c1-3(5)4(6)7-2/h1H2,2H3

2343-89-7 Relevant articles

ONE STEP SYNTHESIS FOR ALKYL 2-FLUOROACRYLATES

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Paragraph 0073-0078, (2021/05/21)

A process is provided that results in an alkyl haloacrylate that is produced by reaction of a dialkyl or diaryl halomalonate with an aldehyde, preferably formalin or paraformaldehyde, and a base catalyst to produce an intermediate that is not isolated and is heated to produce the alkyl haloacrylate. This synthesis can be one pot, meaning it reacts in the same vessel and/or reaction mixture and does not require isolation of the intermediate, and provides an improved yield. In particular, a process is provided that results in an alkyl 2-fluoroacrylate.

METHOD FOR PRODUCING alpha-FLUOROACRYLIC ACID

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Paragraph 0289-0306; 0309-0312; 0315-0320; 0322-0325; 0328-0, (2021/09/03)

An object of the present invention is to provide a novel method for producing an α-fluoroacrylic acid ester compound. This problem is solved by a method for producing a compound represented by formula (1), wherein R1 and R2 are identical or different, and each represents an alkyl group or the like; and R3 is an alkyl group or the like, the method comprising step A of reacting a compound represented by formula (2) with R3—OH (3) and carbon monoxide in the presence of palladium, a double bond-containing compound (α), a diphosphine compound (β), and a base, to obtain the compound represented by formula (1) above.

SYNTHESIS OF METHYL 2-FLUOROACRYLATE

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Paragraph 00103-00106, (2021/10/02)

Methods for the synthesis of methyl 2-fluoroacrylate (MFA) are provided. The methods include use of various hydrofluorination agents using a variety of starting materials and reaction schemes. The methyl 2-fluoroacrylate prepared by the methods described herein can further be used to prepare patiromer calcium sorbitex.

METHOD OF PRODUCING HALOGENATED ACRYLIC ACID ESTER

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Paragraph 0076-0078, (2021/06/25)

PROBLEM TO BE SOLVED: To provide a method allowing production of a halogenated acrylic acid ester in a manner that is safe and convenient and is also suitable for industrial production, without using toxic ingredients. SOLUTION: A method of producing a compound represented by formula (4) includes reacting a compound represented by formula (1) with a compound represented by formula (2) in the presence of a base. [In the formulas, each symbol is as described in the specification.] SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

2343-89-7 Process route

: 2365-93-7
methyl 3-bromo-2-fluoro-2-chloropropanoate

: 2343-89-7
methyl 2-fluoroprop-2-enoate

Conditions

Conditions	Yield
With 10H-phenothiazine; sulfuric acid; zinc; In water; at 82 - 86 ℃; for 0.333333h;	85%
With hydrogen sulfide; sodium N-nitroso-N-phenylhydroxylaminate; zinc; In water; at 100 ℃;	82%
With zinc;	80%
With sulfuric acid; zinc;

: 55900-27-1
methyl 2-fluoro-3-chloropropionate

: 2343-89-7
methyl 2-fluoroprop-2-enoate

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol; sodium phosphate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; under 112.511 - 225.023 Torr;	95%
With dimethyl amine; In diethyl ether; benzene;

2343-89-7 Upstream products

2365-93-7
methyl 3-bromo-2-fluoro-2-chloropropanoate
399-86-0
methyl 3-bromo-2-fluoropropionate
55900-27-1
methyl 2-fluoro-3-chloropropionate
380-26-7
methyl α,β-dibromo-α-fluoropropionate

2343-89-7 Downstream products

99953-33-0
methyl 3-bromo-2,2-difluoropropanoate
1279669-60-1
methyl 1-benzyl-3-fluoropyrrolidine-3-carboxylate
1417912-31-2
(2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate
1417912-32-3
(2R,4S,5R)-dimethyl 5-(3-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate