Product Details;
CasNo： 288-14-2
Molecular Formula： C3H3NO
Appearance： colorless liquid
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288-14-2 Name |
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Name |
isoxazole |
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Synonym |
ISOXAZOLE;1-Oxa-2-azacyclopentadiene;Isooxazole;ISOXAZOLE 98+%;1,2-Oxazole;Isoxazole,99%;Different oxazole;Isoxazole 99% |
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288-14-2 Biological Activity |
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Description |
Isoxazole is a drug scaffold that can be used to develop new drugs with various biological activities (e.g. anti-microbial, anti-viral, anti-cancer, anti-inflammatory, immunomodulatory, anti-convulsant or anti-diabetic properties)[1][2]. |
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Related Catalog |
Research Areas >> Others Signaling Pathways >> Others >> Others |
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References |
[1]. Zhu J, et al. The recent progress of isoxazole in medicinal chemistry. Bioorg Med Chem. 2018 Jul 23;26(12):3065-3075. [2]. Sysak A, et al. Isoxazole ring as a useful scaffold in a search for new therapeutic agents. Eur J Med Chem. 2017 Sep 8;137:292-309. |
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288-14-2 Chemical & Physical Properties |
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Melting point |
-67.1°C |
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Boiling point |
95.5±9.0 °C at 760 mmHg |
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Density |
1.1±0.1 g/cm3 |
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Molecular Formula |
C3H3NO |
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Molecular Weight |
69.062 |
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Flash Point |
8.9±0.0 °C |
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PSA |
26.03000 |
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LogP |
0.08 |
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Exact Mass |
69.021461 |
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Vapour density |
2.4 (vs air) |
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Vapour Pressure |
51.7±0.2 mmHg at 25°C |
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Index of Refraction |
1.422 |
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Storage condition |
Store at RT. |
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288-14-2 Description |
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As an important class of heterocycles, isoxazole is a five membered heterocyclic compound with various pharmacological actions, which is found in some natural products, such as ibotenic acid. It is used in the formation of the basis for a number of drugs, such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV. The isoxazole ring is an essential pharmacophore in modern drug discovery. Some beta-lactamase-resistant antibiotics contain an isoxazole group, including cloxacillin, dicloxacillin, flucloxacillin, and the isoxazole group is also found in some steroid drug such as danazol. |
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288-14-2 Uses |
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Natural insecticide. |
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