Product Details;
CasNo： 7361-61-7
Molecular Formula： C12H16N2S
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7361-61-7 Name |
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Name |
Xylazine |
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Synonym |
2-(2,6-dimethylanilino)-5,6-dihydro-4h-1,3-thiazine;2-(2,6-dimethylphenylamino)-4h-5,6-dihydro-1,3-thiazine;5,6-dihydro-2-(2,6-xylidino)-4h-1,3-thiazine;5,6-dihydro-2-(2,6-xylidino)-4h-3-thiazine;2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine;Xylazine Base & HCL;Xylazine,2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine hydrochloride;Xylazine (200 mg) |
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7361-61-7 Biological Activity |
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Description |
Xylazine is α2 class of adrenergic receptor agonist.Target: Adrenergic ReceptorXylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). We concluded that xylazine given by epidural injection results in safe, effective perineal analgesia in horses [2]. |
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Related Catalog |
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease |
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References |
[1]. Reyes, J.C., et al., The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico. J Urban Health, 2012. 89(3): p. 519-26. [2]. Hsu, W.H., Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J Pharmacol Exp Ther, 1981. 218(1): p. 188-92. |
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7361-61-7 Chemical & Physical Properties |
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Melting point |
140ºC |
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Boiling point |
334.2±52.0 °C at 760 mmHg |
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Density |
1.2±0.1 g/cm3 |
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Molecular Formula |
C12H16N2S |
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Molecular Weight |
220.334 |
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Flash Point |
155.9±30.7 °C |
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PSA |
49.69000 |
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LogP |
2.37 |
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Exact Mass |
220.103424 |
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Vapour Pressure |
0.0±0.7 mmHg at 25°C |
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Index of Refraction |
1.611 |
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Storage condition |
−20°C |
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7361-61-7 Description |
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Xylazine is an agonist of α2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an α2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard . |
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7361-61-7 Uses |
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