65-28-1
- Product Name：Phentolamine mesilate
- Molecular Formula：C18H23N3O4S
- Purity：99%
- Molecular Weight：
Product Details;
CasNo： 65-28-1
Molecular Formula： C18H23N3O4S
Appearance： white to off-white crystalline solid
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65-28-1 Name |
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Name |
Phentolamine mesilate |
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Synonym |
REGITIN;REGITIN MESYLATE;PHENTOLAMINE MESILATE;PHENTOLAMINE MESYLATE;PHENTOLAMINE METHANESULFONATE;PHENTOLAMINE METHANESULFONATE SALT;VASOMAX;m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-phenomonomethanesulfonate(sal |
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65-28-1 Biological Activity |
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Description |
Phentolamine mesylate is a competitive, reversible α-adrenoceptor antagonist with an IC50 between 5 and 30 nM. |
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Related Catalog |
Signaling Pathways >> GPCR/G Protein >> Adrenergic ReceptorResearch Areas >> Cardiovascular Disease |
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References |
[1]. Giussani, D.A., et al., Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero. J Physiol, 1995. 486 ( Pt 1): p. 249-55. [2]. Saeed, M., et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade. J Cardiovasc Pharmacol, 1982. 4(1): p. 44-52. |
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65-28-1 Chemical & Physical Properties |
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Melting point |
180-182 °C(lit.) |
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Boiling point |
551ºC at 760 mmHg |
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Density |
1.2256 (rough estimate) |
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Molecular Formula |
C18H23N3O4S |
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Molecular Weight |
377.458 |
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Flash Point |
287ºC |
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PSA |
110.61000 |
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LogP |
3.18960 |
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Exact Mass |
377.140930 |
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Storage condition |
Refrigerator |
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Stability |
Aq. Solutions Cannot be Stored |
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Water Solubility |
50 MG/ML |
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65-28-1 Description |
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Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis. |
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65-28-1 Uses |
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Phentolamine mesilate is an adrenergic blocking agent and antihypertensive. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease. |
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