64603-91-4
- Product Name：THIP HYDROCHLORIDE
- Molecular Formula：C6H8 N2 O2
- Purity：99%
- Molecular Weight：
Product Details;
CasNo： 64603-91-4
Molecular Formula： C6H8 N2 O2
Appearance： white solid
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64603-91-4 Name |
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Name |
THIP HYDROCHLORIDE |
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Synonym |
THIP HYDROCHLORIDE;4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3(2h)-onehydrate;4-c)pyridin-3(2h)-one,4,5,6,7-tetrahydro-isoxazolo(hydrate;gaboxadol;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL HYDROCHLORIDE;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one;THIP |
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64603-91-4 Biological Activity |
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Description |
THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1]. |
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Related Catalog |
Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor |
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Target |
α4β3δ GABAAR:13 μM (EC50) |
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References |
[1]. Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34(49):16256-72. |
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64603-91-4 Chemical & Physical Properties |
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Melting point |
242-244° (dec) |
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Boiling point |
340.5±42.0 °C at 760 mmHg |
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Density |
1.3±0.1 g/cm3 |
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Molecular Formula |
C6H9ClN2O2 |
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Molecular Weight |
140.140 |
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Flash Point |
159.7±27.9 °C |
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PSA |
58.29000 |
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LogP |
-0.61 |
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Exact Mass |
140.058578 |
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Vapour Pressure |
0.0±0.8 mmHg at 25°C |
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Index of Refraction |
1.551 |
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64603-91-4 Description |
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Gaboxadol HCl (64603-91-4) is a GABA-A receptor agonist. Hypnotic agent. |
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64603-91-4 Uses |
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GABAa agonist, GABAc antagonist |
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