665-66-7
- Product Name：1-Adamantanamine hydrochloride
- Molecular Formula：C10H18ClN
- Purity：99%
- Molecular Weight：
Product Details;
CasNo： 665-66-7
Molecular Formula： C10H18ClN
Appearance： Crystalline solid
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665-66-7 Name |
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Name |
1-Adamantanamine hydrochloride |
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Synonym |
Amantadine hydrochloride,1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride;Amantadine Hydrochloride (200 mg);1-AdaMantanaMine hydrochloride, 99+% 100GR;1-AdaMantanaMine hydrochloride, 99+% 25GR;1-AdaMantanaMine hydrochloride, 99+% 5GR;1-adamantane amine hydrochloride;1-Adamantanamine Hydrochleride;1-Aminoadamantane Hydrochloride Amantadine Hydrochloride |
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665-66-7 Chemical & Physical Properties |
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Melting point |
>300 °C(lit.) |
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Boiling point |
225.7ºC at 760 mmHg |
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Density |
1.067g/cm3 |
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Molecular Formula |
C10H18ClN |
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Molecular Weight |
187.710 |
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Flash Point |
96ºC |
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PSA |
26.02000 |
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LogP |
3.41620 |
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Exact Mass |
187.112778 |
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Index of Refraction |
1.558 |
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Water Solubility |
soluble |
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665-66-7 Description |
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Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.Target: Influenza VirusAmantadine is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. Amantadine binding of M2, based on studies of a peptide representing the M2 transmembrane segment in dodecylphosphocholine micelles. Amantadine competes with protons for binding to the deprotonated tetramer, thereby stabilizing the tetramer in a slightly altered conformation. This model accounts for the observed inhibition of proton flux by amantadine [1]. In contrast to most other described channel-blocking molecules, amantadine causes the channel gate of NMDA receptors to close more quickly. Amantadine binding inhibits current flow through NMDA receptor channels but show that its main inhibitory action at pharmaceutically relevant concentrations results from stabilization of closed states of the channel |
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665-66-7 Uses |
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