Product classification

537-98-4

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CasNo： 537-98-4

Molecular Formula： C₁₀H₁₀O₄

Appearance： solid

537-98-4 Name
Name	trans-Ferulic acid
Synonym	(E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid;(e)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoicacid;(e)-ferulicacid;3-(4-Hydroxy-3-methoxyphenyl)propenoic acid;Cinnamic acid, 4-hydroxy-3-methoxy-, (E)-;Cinnamic acid, 4-hydroxy-3-methoxy-, trans-;Ferulic acid, trans-;trans-cinnamic

537-98-4 Biological Activity
Description	(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Bax
References	[1]. Fong Y, et al. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med. 2016 Oct 1;11:45.

537-98-4 Chemical & Physical Properties
Melting point	168-172ºC
Boiling point	372.3±27.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Molecular Formula	C10H10O4
Molecular Weight	194.184
Flash Point	150.5±17.2 °C
PSA	66.76000
LogP	1.64
Exact Mass	194.057907
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.627
Stability	Stable. Incompatible with strong oxidizing agents.

537-98-4 Uses

trans-Ferulic acid was used for esterification of methacrylated dextran. It was also used to study the effect of oral administration of trans-ferulic acid to c57BL mice on ethanol-induced liver injury. Furthermore, it has been used in the synthesis of new biocompatible antioxidant polymers linking trans-ferulic acid.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.