1094-61-7
- Product Name：BETA-NICOTINAMIDE MONONUCLEOTIDE
- Molecular Formula：C11H15 N2 O8 P
- Purity：99%
- Molecular Weight：
Product Details;
CasNo： 1094-61-7
Molecular Formula： C11H15 N2 O8 P
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1094-61-7 Name |
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Name |
β-Nicotinamide Mononucleotide |
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Synonym |
NMN;BETA-NMN;BETA-NICOTINAMIDE MONONUCLEOTIDE;BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE;3-(aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;B-NICOTINAMIDE MONONUCLEOTIDE;NMN;NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE;NICOTINAMIDE RIBOTIDE |
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1094-61-7 Biological Activity |
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Description |
β-nicotinamide mononucleotide is an intermediate in NAD+ biosynthesis produced from nicotinamide (NAM) and phosphoribosyl pyrophosphate (PRPP) by nicotinamide phosphoribosyl transferase enzyme. |
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Related Catalog |
Natural Products >> Saccharides and Glycosides Research Areas >> Others |
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Target |
Human Endogenous Metabolite |
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1094-61-7 Chemical & Physical Properties |
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Melting point |
166 °C(dec.) |
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solubility |
DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) |
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Molecular Formula |
C11H15N2O8P |
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Molecular Weight |
334.219 |
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LogP |
-3.38 |
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PSA |
176.06000 |
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Exact Mass |
334.056610 |
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Storage condition |
2-8°C |
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1094-61-7 Description |
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β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+. |
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1094-61-7 Uses |
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β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra. β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels. |
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