520-18-3

520-18-3 Biological Activity

Description

Kaempferol inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK.

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Signaling Pathways >> Autophagy >> Mitophagy

Research Areas >> Cancer

Natural Products >> Flavonoids

Target

Estrogen receptor[1]

In Vivo

The COX2 induction is confirmed in the airways of BSA-challenged BALB/c mice. There is lack of COX2 in airways of untreated control mice observed. The BSA inhalation to mice led to enhanced COX2 induction (dark brown staining) in mouse airway, which is reversed by oral administration of Kaempferol. In BSA-challenged mice, there is a marked goblet cell hyperplasia and epithelial thickening observed. When 20 mg/kg Kaempferol is supplemented to BSA-challenged mice, the epithelial thickening completely disappeared[4].

References

[1]. Luo H, et al. Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability. Int J Nanomedicine. 2012; 7: 3951-3959.

[2]. Luo H, et al. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011 September 15; 128(2): 513-519.

[3]. An M, et al. Protective effects of Kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. Anat Cell Biol. 2015 Dec;48(4):235-43.

[4]. Shin D, et al. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16(12):29980-95.

520-18-3 Chemical & Physical Properties

Melting point 

276°C

Boiling point

582.1±50.0 °C at 760 mmHg

Density

1.7±0.1 g/cm3

Molecular Formula

C15H10O6

Molecular Weight

286.236

Flash Point

PSA

111.13000

LogP

2.05

Exact Mass

286.047729

Vapour Pressure

0.0±1.7 mmHg at 25°C

Index of Refraction

1.785

Storage condition

−20°C

Water Solubility

ethanol: 20 mg/mL