Product Details;
CasNo： 130-85-8
Molecular Formula： C23H16O6
Appearance： Fine Yellow Powder
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130-85-8 Name |
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Name |
Pamoic acid |
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Synonym |
PAMOIC ACID;EMBONIC ACID;EMBIONIC ACID;Pamoic;2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy-;1,1'-methylene-bis(2-hydroxy-3-naphthoic acid);PAMOIC ACID pure;1,1μ-Methylene-bis(2-hydroxy-3-naphthoic acid), 4,4μ-Methylenebis(3-hydroxy-2-naphthoic acid), Embonic acid |
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130-85-8 Biological Activity |
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Description |
Pamoic acid is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties[1][2]. |
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Related Catalog |
Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK |
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Target |
EC50: 79 nM (GPR35)[1] |
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In Vitro |
GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes[1]. |
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In Vivo |
In a mouse model of stroke, that GPR35 activation by Pamoic acid (s.c.; 50-100 mg/kg) is neuroprotective. Pharmacological inhibition of GPR35 reveals that Pamoic acid reduces infarcts size in a GPR35 dependent manner. Pamoic acid treatment results in a preferential increment of noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain along with the reduced neutrophil counts[1]. |
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References |
[1]. Ozayra Sharmin, et al. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sci Rep. 2020 Jun 10;10(1):9400.[2]. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8. |
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130-85-8 Chemical & Physical Properties |
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Melting point |
≥300 °C (dec.) |
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Boiling point |
642.7±55.0 °C at 760 mmHg |
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Density |
1.5±0.1 g/cm3 |
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Molecular Formula |
C23H16O6 |
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Molecular Weight |
388.38 |
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Flash Point |
356.5±28.0 °C |
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PSA |
115.06000 |
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LogP |
6.35 |
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Exact Mass |
388.094696 |
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Vapour Pressure |
0.0±2.0 mmHg at 25°C |
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Index of Refraction |
1.782 |
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Water Solubility |
PRACTICALLY INSOLUBLE |
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130-85-8 Description |
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Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
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130-85-8 Uses |
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Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases. |
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