1985605-59-1
- Product Name：Baloxavir CAS NO.: 1985605-59-1
- Molecular Formula：
- Purity：99%
- Molecular Weight：
Product Details;
CasNo： 1985605-59-1
Appearance： Colorless liquid
Delivery Time： In stock
Throughput： 10000|Metric Ton|Month
Purity： 99%
| Baloxavir Usage And Synthesis |
| Uses | Baloxavir is a drug employed in the treatment of influenza virus infection. Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents. |
| Uses | Baloxavir is a drug employed in the treatment of influenza virus infection. |
| Mechanism of action | Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir. |
| Side effects | Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir. |
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