Product classification

118525-40-9

Product Name：Icaritin
Molecular Formula：C₂₁H₂₀O₆
Purity：99%
Molecular Weight：

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Product Details;

CasNo： 118525-40-9

Molecular Formula： C₂₁H₂₀O₆

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Icaritin 118525-40-9 In Bulk Supply with Wholesale Price

Molecular Formula:C21H20O6
Molecular Weight:368.386
Vapor Pressure:3.82E-14mmHg at 25°C
Melting Point:239 °C
Refractive Index:1.656
Boiling Point:581.992 °C at 760 mmHg
PKA:6.44±0.40(Predicted)
Flash Point:206.679 °C
PSA：100.13000
Density:1.36 g/cm³
LogP:4.09410

118525-40-9 Usage

Lcaritin is Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from epimedium. Icaritin is a compound derived from the Epimedium plant, also known as horny goat weed. It has been studied for its potential health benefits, including its ability to promote bone health, improve cognitive function, and even exhibit anti-cancer properties. However, further research is still needed to fully understand its effects on human health. They also have significant antiangiogenesis properties, inhibiting or eliminating entirely the development of new malignant cells. Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC).

InChI:InChI=1/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3

118525-40-9 Relevant articles

Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen - Cope rearrangement

Mei, Qinggang,Wang, Chun,Zhao, Zhigang,Yuan, Weicheng,Zhang, Guolin

, p. 1220 - 1225 (2015)

The hemisynthesis of the naturally occurring bioactive flavonoid glycoside icariin (1) has been accomplished in eleven steps with 7% overall yield from kaempferol. The 4?-OH methylation of kaempferol, the 8-prenylation of 3-O-methoxymethyl-4?-O-methyl-5- O-prenyl-7-O-benzylkaempferol (8) via para-Claisen-Cope rearrangement catalyzed by Eu(fod)3 in the presence of NaHCO3 , and the glycosylation of icaritin (3) are the key steps.

A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells

Huang, Xin,Zhu, Danyan,Lou, Yijia

, p. 26 - 36 (2007)

Icariin and icaritin with prenyl group have been demonstrated for their selective estrogen receptor modulating activities. These findings suggested a novel anticancer efficacy of icaritin mediated selectively via induction of cell cycle arrest but not associated with estrogen receptors in PC-3 cells.

Magnesium dicarboxylates promote the prenylation of phenolics that is extended to the total synthesis of icaritin

Fu, Xuewen,Lu, Xiaoxia,Wang, Chun,Wen, Yongju,Xiong, Wei,Zhang, Guolin,Zhang, Jichao

, p. 1117 - 1124 (2022/02/16)

The prenylation of phenolic substrates promoted by magnesium dicarboxylates was developed. An investigation of the scope demonstrated that substrates with electron-donating group(s) gave better yields than those with electron-withdrawing group(s). Althoug

Convenient and efficient total synthesis method for icaritin and derivatives of icaritin

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Paragraph 0063; 0084-0088, (2020/02/06)

The invention belongs to the field of natural medicine synthesis and particularly relates to a convenient and efficient total synthesis method for icaritin and derivatives of icaritin. The total synthesis method provided by the invention is mild in condition, convenient to operate, high intotal yield and suitable for mass production of the isopentenyl flavone compound.

ANALOGS OF THE NATURAL PRODUCT ICARIIN

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Paragraph 00168; 00192, (2020/03/02)

Provided herein are analogs of the natural product icariin represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The analogs can be used to modulate (e.g., inhibit, such as by competitive inhibition) PDE5 and thereby treat a wide range of PDE5- mediated diseases, including cardiovascular, gastrointestinal, pulmonary, musculoskeletal, neurological and reproductive diseases. Also provided herein are compositions and methods including compounds of Structural Formula (I).

118525-40-9 Process route

epimedium koreanum Nakai, leaves; 1-butanol-ether-hexane-methanol extract of: epimedium koreanum Nakai, leaves; 1-butanol-ether-hexane-methanol extract of

: 118525-40-9
icaritin

: 113558-15-9
icariside II

: 56725-99-6
3-hydroxy-7-O-β-glucose-8-prenyl-4'-methoxychrysin

Conditions

Conditions	Yield
With hydrogenchloride; methanol; water; at 80 ℃; for 8h; Product distribution / selectivity; Heating / reflux;
With sodium methylate; In pyridine; at 80 ℃; for 8h; Product distribution / selectivity; Heating / reflux;
With acetic acid; β-glucuronidase; naringinase; hesperidinase; β-galactosidase; cellulase; amyloglucosidase; at 37 ℃; for 48h; pH=4.5; Product distribution / selectivity;
epimedium koreanum Nakai, leaves; 1-butanol-ether-hexane-methanol extract of; With water; at 121 ℃; for 0.5h; at 30 ℃; for 120h; Product distribution / selectivity;

: 7-(benzyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one

: 118525-40-9
icaritin