832720-36-2
- Product Name：NBI 56418NA
- Molecular Formula：C32H29F5N3NaO5
- Purity：99%
- Molecular Weight：
Product Details;
CasNo： 832720-36-2
Molecular Formula： C32H29F5N3NaO5
Henan Wentao Chemical Product Co., Ltd. is a quality supplier and manufacturer of NBI 56418NA . You can buy High Purity Pharmaceutical Intermediates NBI 56418NA 832720-36-2 here. Contact us.
High Purity Pharmaceutical Intermediates NBI 56418NA 832720-36-2
- Molecular Formula:C32H29F5N3NaO5
- Molecular Weight:653.5715
- PSA：105.39000
- LogP:4.59120
NBI 56418NA 832720-36-2 Usage
NBI 56418NA is a small molecule, orally active gonadotropin-releasing hormone (GnRH) receptor antagonist. In July 2018, the U.S. Food and Drug Administration (FDA) approved elagolix sodium for the management of moderate to severe pain associated with endometriosis, after the drug showed promising efficacy and safety results in previous phase III trials. Formulations containing elagolix have been used in the treatment of endometriosis.
InChI:InChI=1/C32H30F5N3O5.Na/c1-19-28(21-11-6-14-26(45-2)29(21)34)30(43)40(18-25(20-9-4-3-5-10-20)38-16-8-15-27(41)42)31(44)39(19)17-22-23(32(35,36)37)12-7-13-24(22)33;/h3-7,9-14,25,38H,8,15-18H2,1-2H3,(H,41,42);/q;+1/p-1/t25-;/m0./s1
832720-36-2 Relevant articles
LC–MS-Compatible Chromatographic Method for Quantification of Potential Organic Impurities of Elagolix Sodium in Tablet Dosage Form with Identification of Major Degradation Products
Pritesh Desai, Rohit Prajapati, Avani Chokshi
Journal of AOAC INTERNATIONAL, Volume 106, Issue 3, May-June 2023, Pages 568–579
NBI 56418NA and its prominent organic impurities were resolved in the developed method through a gradient elution program of 46 min at a flow rate of 1.3 mL/min.
Evolution of Stability-Indicating Method in the Quantification of Related Substances and Degradation Products of Elagolix Sodium: Quality by Design-Driven Approach Utilizing Ultra-high Performance Liquid Chromatography
Sivaganesh Bommi, Subbalakshmi Jayanty, Satyanarayana Raju Tirumalaraju, Suresh Kola & Venkata Siva Rama Krishna Reddy Kallam
Chromatographia volume 86, pages31–42 (2023)
However, regarding Elagolix sodium (NBI 56418NA), analytical methods to quantify all its potential-related impurities along with its precursor intermediates used for the synthesis of ELX are yet unavailable.
Relevant Products
-
5'-Deoxy-5-fluorocytidineCAS：66335-38-4
-
Antioxidant 5057CAS：68411-46-1
-
Ethyl 4-[[(methylphenylamino)methylene]amino]benzoateCAS：57834-33-0
