Product classification

979-32-8

Product Name：Estradiol valerate
Molecular Formula：C₂₃H₃₂O₃
Purity：99%
Molecular Weight：

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Product Details;

CasNo： 979-32-8

Molecular Formula： C₂₃H₃₂O₃

Appearance： Na

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979-32-8 Chemical & Physical Properties
Melting point	144°C
Boiling point	486.2±45.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Molecular Formula	C23H32O3
Molecular Weight	356.498
Flash Point	191.1±21.5 °C
PSA	46.53000
LogP	6.62
Exact Mass	356.235138
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.568
storage temp.	Sealed in dry,Room Temperature
solubility	Practically insoluble in water, soluble in alcohol.

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Estradiol valerate (EV) is White to off-white crystalline powder, odorless. Insoluble in water, easily soluble in ethanol, acetone, chloroform, slightly soluble in vegetable oil. Estradiol valerate is a hormone that is utilised in the treatment of a variety of conditions, including transgender women, menopausal symptoms, low oestrogen levels, and hormonal birth control. It is used to reduce symptoms of menopause which are vaginal dryness, hot flashes, and others. Estradiol valerate is commercially available as an intramuscular injection. Estradiol valerate (EV) has been developed to reduce the effects on the coagulation system and lower the VTE risk.

InChI:InChI=1/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18?,19?,20?,21-,23-/m0/s1

979-32-8 Relevant articles

Estradiol Valerate vs Ethinylestradiol in Combined Oral Contraceptives: Effects on the Pituitary-Ovarian Axis

Annina Haverinen, Kaisu Luiro, Marika H Kangasniemi, Terhi T Piltonen, Steinar Hustad, Oskari Heikinheimo, Juha S Tapanainen

The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 7, July 2022, Pages e3008–e3017

To compare estradiol valerate (EV) + dienogest (DNG), EE + DNG, and DNG alone (active control) on levels of follicle stimulating hormone (FSH), luteinizing hormone, anti-Müllerian hormone (AMH), ovarian steroids, sex hormone binding globulin (SHBG), and the free androgen index (FAI).

Effects of 24-hour oral estradiol-valerate administration on hormone levels in men and pre-menopausal women

G Rune, G Joue, T Sommer

Psychoneuroendocrinology, 2023

A large body of evidence has been collected in animal experiments on the manifold effects of 17β-estradiol (E2) mainly in the hippocampus, but also in the prefrontal cortex and on the dopaminergic system, with observable changes in behavior (Luine, 2014, Taxier et al., 2020).

979-32-8 Process route

: 63042-28-4
estradiol divalerate

: 979-32-8,25918-99-4,300853-47-8
estradiol 17-valerate

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate; at 40 - 45 ℃; for 2h;	74%
With sodium tetrahydroborate; In methanol; at 40 - 45 ℃; for 2h;	74%
With sodium hydroxide;
With methanol; potassium carbonate; at 20 ℃;

: 63042-21-7
3-benzoyloxy-17β-valeryloxy-estra-1,3,5(10)-triene

: 979-32-8,25918-99-4,300853-47-8
estradiol 17-valerate